Temporal Gradients in Shear, but Not Spatial Gradients, Stimulate Endothelial Cell Proliferation
نویسندگان
چکیده
منابع مشابه
Temporal gradients in shear, but not spatial gradients, stimulate endothelial cell proliferation.
BACKGROUND The effect of temporal and spatial gradients in shear on primary human endothelial cell (HUVEC) proliferation was investigated. The sudden-expansion flow chamber (SEFC) model was used to differentiate the effect of temporal gradients in shear from that of spatial gradients. With a sudden onset of flow, cells are exposed to both temporal and spatial gradients of shear. The temporal gr...
متن کاملTemporal gradients in shear, but not spatial gradients, stimulate ERK1/2 activation in human endothelial cells.
We have previously demonstrated temporal gradients in shear stress stimulate endothelial cell proliferation, whereas spatial gradients do not. In the present study, the extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathway was investigated as a possible mediator for the promitogenic effect of temporal gradients. The sudden expansion flow chamber (SEFC) model was used to differentiate ...
متن کاملTemporal gradients in shear stimulate osteoblastic proliferation via ERK1/2 and retinoblastoma protein.
Bone cells are subject to interstitial fluid flow (IFF) driven by venous pressure and mechanical loading. Rapid dynamic changes in mechanical loading cause transient gradients in IFF. The effects of pulsatile flow (temporal gradients in fluid shear) on rat UMR106 cells and rat primary osteoblastic cells were studied. Pulsatile flow induced a 95% increase in S-phase UMR106 cells compared with st...
متن کاملSpatial and temporal gradients in the cosmological constant
It is possible that there may be differences in the fundamental physical parameters from one side of the observed universe to the other. I show that the cosmological constant is likely to be the most sensitive of the physical parameters to possible spatial variation, because a small variation in any of the other parameters produces a huge variation of the cosmological constant. It therefore pro...
متن کاملOn spatial power gradients
The variation of the instantaneous power versus distance for a narrowband channel is an important parameter in modern digital systems, relevant for variations during a burst and for power control algorithms. This paper gives the statistical distribution for the power gradient, both in decibels and in natural units for a Rayleigh fading channel. The former has been known for some time to be Stud...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 2001
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.103.20.2508